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 organ on a chip model offers insights into premature aging and vascular disease
organ-on-a-chip model offers insights into premature aging and vascular disease

Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic condition that causes premature and accelerated aging. Recently, researchers have been able to generate induced pluripotent stem cells from patients with HGPS to better understand the mechanisms of aging and look for new treatments.

organ-on-a-chip model offers insights into premature aging and vascular disease

Photograph of the microfluidic channel showing the media inlet and outlet. Credit: Joao Ribas, Brigham and Women's HospitalHutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic condition that causes premature and accelerated aging. Recently, researchers have been able to generate induced pluripotent stem cells from patients with HGPS to better understand the mechanisms of aging and look for new treatments.
HGPS primarily affects vascular cells, which undergo biomechanical strains in blood vessels. However, the impact of these biomechanical strains on aging and vascular diseases has been challenging to study in the lab as most models fail to mimic the biomechanics that cells experience in the body. Using a new progeria-on-a-chip model, investigators from Brigham and Wom

organ-on-a-chip model offers insights into premature aging and vascular disease

IMAGE: Physiological strain induces a contractile phenotype in primary
smooth muscle cells.
view more Credit: Joao Ribas, Brigham and Women's HospitalHutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic condition that causes premature and accelerated aging. Recently, researchers have been able to generate induced pluripotent stem cells from patients with HGPS to better understand the mechanisms of aging and look for new treatments. HGPS primarily affects vascular cells, which undergo biomechanical strains in blood vessels. However, the impact of these biomechanical strains on aging and vascular diseases has been challenging to study in the lab as most models fail to mimic the biomechanics that cells experience in the body. Using a new progeria-on-a-chip model, invest

how an atari chip set off a war among neuroscientists

Neuroscientists may have plenty of bottom-up data about the brain, but they're far from using that data to understand how the ont style="color:#666;background-color:#fff5a9;">organont> works. The post How an Atari Chip Set Off a War Among Neuroscientists appeared first on WIRED.

how an atari chip set off a bitter war among neuroscientists

Neuroscientists may have plenty of bottom-up data about the brain, but they're far from using that data to understand how the ont style="color:#666;background-color:#fff5a9;">organont> works. The post How an Atari Chip Set Off a Bitter War Among Neuroscientists appeared first on WIRED.

the 9.7-inch ipad pro 2 could launch without a special event

According to the report, the new 9.7-inch iPad Pro could launch with the same specifications as the current model, except for the introduction of an “A10X” chip. The chip, an enhanced version of the A10 found on the iPhone 7, would replace the A9X chip on the current tablet model.If this occurs, the current model will replace the iPad Air 2 as the entry-level 9.7-inch tablet in Apple’s lineup. For now, the 9.7-inch iPad Pro with A9X chip has an entry price of $599, while the A8X-powered iPad Air 2 starts at $399.What about the other 2017 iPads?It’s been rumored that Apple will unveil at least three new iPads this year. Besides the 9.7-inch iPad Pro 2, there could be a new “10.5-inch iPad Pro” and second-generation 12.9-inch iPad Pro. The 10.5-inch iPad Pro is likely to ship bezel-free usin

presstv-lebanon hospital takes iran as model organ donation

Mariam SalehPress TV, BeirutA number of hospitals in Lebanon have launched a project to raise public awareness about the significance of ont style="color:#666;background-color:#fff5a9;">organont> donation and its life-saving role. There is still some serious resistance against the operation with many viewing it as a religious taboo. Our correspondent in Beirut, Mariam Saleh has visited one of these hospitals and filed this report.

the still-misunderstood shape of the clitoris

Can a 3-D printed model of the ont style="color:#666;background-color:#fff5a9;">organont> change views on female sexuality? Yes and no. An Object Lesson

benefits of physical activity may outweigh impact of obesity on cardiovascular d

Sophia Antipolis, March 1, 2017: The benefits of physical activity may outweigh the impact of overweight and obesity on cardiovascular disease in middle-aged and elderly people, according to research published today in the European Journal of Preventive Cardiology.1 The observational study was conducted in more than 5,000 people aged 55 years and older who were followed-up for 15 years."Overweight and obesity is associated with a higher risk of cardiovascular disease and it is recommended to lose weight," said author Dr Klodian Dhana, a postdoctoral researcher in the Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, the Netherlands. "But in the elderly this is slightly different because weight loss, especially unintentional, is associated with muscle loss and death.

rna and longevity: discovering the mechanisms behind aging

The vigors of youth and the greener pastures of yesteryears. Some might refer to these and other similar clichés as nothing more than rose-tinted literations of the past; a cognitive side effect of life. Romanticizing collective memories aside, however, it would be a challenge to find anyone who could argue against the physical degradations that accompany aging. One needs only to search for 'photos of aging' to realize that such yearnings are perhaps nothing more than ourselves giving form to the personal struggle with the byproducts of life. What if, though, human beings could harness the power to control aging? Scientists have long strived to understand the aging process in order to combat age-related diseases and attain longevity. However, a complete picture of the inherently complex un

beyond smartphones, samsung wants its exynos 9 chip in vr headsets

In a room cordoned off from the Mobile World Congress audience, Samsung was showing off untethered headsets that operate independent of smartphones.These were prototype devices meant mainly to show off the processing power of its Exynos chips. Samsung already offers tethered Gear VR headsets, but now wants outside companies to use its latest Exynos 9 chip in untethered VR headsets and smartphones of their own.Exynos chips have been more of an internal project for Samsung, and have been used in the company's Galaxy phones. Just a handful of outside phone makers, like Meizu, have used the chips in their handsets.But Samsung finally seems to be realizing that they have a great product with Exynos 9, a powerful chip that can drive a new generation of smartphones and VR headsets. The company is

molecular structure of the cell nucleoskeleton revealed for the first time

Using 3-D electron microscopy, structural biologists from the University of Zurich succeeded in elucidating the architecture of the lamina of the cell nucleus at molecular resolution for the first time. This scaffold stabilizes the cell nucleus in higher eukaryotes and is involved in ont style="color:#666;background-color:#fff5a9;">organont>izing, activating and duplicating the genetic material. Diseases such as muscular dystrophy and premature aging, caused by mutations in the lamin gene, the major constituent of the lamina, can now be studied more effectively.

toshiba offers memory chip shares as collateral for loans: sources

Reuters  | 
Tokyo  March 15, 2017 Last Updated at 18:29 IST

music thing modular intros chord organ eurorack module – synthtopia

Music Thing Modular has introduced Chord Organ – an alternate firmware for the Music Thing Modular Radio Music module that transforms it into a polyphonic chord tone generator.Chord ont style="color:#666;background-color:#fff5a9;">organont> is very simple:Chord = choose the chord shape; minor, major, seventh etc. Shapes can be defined by editing a text file on the SD Card (see below). Chords can have up to 8 notes.Root = choose the root note, in semitones from C-2 to C+2Waveform = push to select one of four waveforms: Sine, Square, Sawtooth and weird-gnarly-pulse-an-octave-below.Chord + Root CV inputs. The Root CV input is NOT volt/octave, but the output notes are perfectly in standard tuning (A = 440hz).Trig = Trigger output, which pulses every time the chord changesOut = Audio outputHere’s what developer Tom Whitwell has to say about Chord

intel’s 15 billion reasons why an ai chip revolution has arrived

The world's largest chip maker is on an AI chip spending spree. The post Intel’s 15 Billion Reasons Why an AI Chip Revolution Has Arrived appeared first on WIRED.

controlling energy production by calcium is an organ-specific affair

PHILADELPHIA (March 7, 2017) -- A heart beat begins with a rush of calcium into the heart cell followed by a burst of energy from the resident mitochondria. These two events occur with each beat. Yet these events are not confined to heart cells and in fact occur in the cells of many other ont style="color:#666;background-color:#fff5a9;">organont>s. A fundamental question researchers have asked is how different patterns of calcium intake can be linked to the very different energy needs of, for example, an incessantly beating heart cell compared to a liver cell that receives less regular calcium signals.Now, researchers at Thomas Jefferson University have shown that the composition of the mitochondrial calcium portal (the protein that regulates when and how much calcium enters) is different depending on the ont style="color:#666;background-color:#fff5a9;">organont> in the body, and this differen

life, death, math, and efficiency: the quest to solve us organ transplant woes

Enlarge/ As Stephen Merritt once sang, "I think I need a new heart." Getty ImagesShare this storyIn 2009, Steve Jobs received a liver transplant—not in northern California where he lived, but across the country in Memphis, Tennessee. Given the general complications of both travel and a transplant, Jobs’ decision may seem like an odd choice. But it was a strategic move that almost certainly got him a liver much more quickly than if Jobs had just waited for a liver to become available in California. Eight years later, the Apple founder’s procedure continues to highlight the state of transplants in the US: when it comes to ont style="color:#666;background-color:#fff5a9;">organont>s, we have a big math problem.Today, there’s a much greater need than there are ont style="color:#666;background-color:#fff5a9;">organont>s to go around. It’s a problem currently being tackled in part by mathematicians a

study sheds light on interactions that change the way heat and electricity move

New research offers insights into how crystal dislocations—a common type of defect in materials—can affect electrical and heat transport through crystals, at a microscopic, quantum mechanical level.

music thing modular intros chord organ eurorack module

Music Thing Modular has introduced Chord Organ - an alternate firmware for the Music Thing Modular Radio Music module that transforms it into a polyphonic chord tone generator. … Read More Music Thing Modular Intros Chord Organ Eurorack Module

the best fitbit trackers of 2017

Fitbit, currently one of the most well-known names in the fitness tracking world, has seven different trackers on sale right now. Which one is right for you? Should you pick up one of the new fashion-forward devices like the Alta or Blaze, or should you consider an older one like the Surge or Charge 2?With devices ranging anywhere from $60-$250, there’s certainly a wide range of options from which to choose. So with that said, read on to find out which Fitbit is right for you.Related:The best fitness trackers3 days agoUpcomingFitbit Alta HR2016’s Fitbit Alta is still one of our favorite fitness trackers on the market, and now Fitbit is back with an upgraded model. The new Fitbit Alta HR brings an optical heart rate sensor, an improved design, and a bevy of new sleep tracking features, all

barrels of fun: oskar blues opens new event venue in longmont

If you goWhat: Oak Room grand openingWhen: 5-7:30 p.m. Saturday, Feb. 25Where: Oak Room at the Longmont Brewery, 1800 Pike RoadOn tap: Special beers on tap, live music, parade and stiltwalkersMore info:facebook.com/events/132090277306491/Old beer is in, and it's helping one local brewery grow. Longmont-based Oskar Blues is opening its new event space, Oak Room, this weekend in a Mardi-Gras themed party open to the publicThe 4,275-square-foot space is adjacent to Oskar Blues' barrel-aging room and, in fact, came about because of the need to store the brewery's growing collection of maturing beers."Our barrel aging program was really picking up, and we needed space for that," said Chad Melis, marketing director for Oskar Blues. "The oak barrels were really good looking, and that inspired the

barrels of fun: oskar blues opens new event venue in longmont

If you goWhat: Oak Room grand openingWhen: 5-7:30 p.m. Saturday, Feb. 25 (Doors open at 3 p.m.)Where: Oak Room at the Longmont Brewery, 1800 Pike RoadOn tap: Special beers on tap, live music, parade and stiltwalkersMore info:facebook.com/events/132090277306491/Old beer is in, and it's helping one local brewery grow. Longmont-based Oskar Blues is opening its new event space, Oak Room, this weekend in a Mardi-Gras themed party open to the publicThe 4,275-square-foot space is adjacent to Oskar Blues' barrel-aging room and, in fact, came about because of the need to store the brewery's growing collection of maturing beers."Our barrel aging program was really picking up, and we needed space for that," said Chad Melis, marketing director for Oskar Blues. "The oak barrels were really good looking

new insights on how pathogens escape the immune system

Our immune system has various ways to deal with threats from the outside like pathogens. One of the defence mechanisms is a process called autophagy. 'You can imagine autophagy as the vacuum cleaner of the cell', says Nirmal Robinson, leading scientist of the study. 'It keeps the cell clean by clearing and degrading pathogens or damaged parts of the cell.' This prevents the toxic accumulation of cellular waste and thus preserves the function of cellular ont style="color:#666;background-color:#fff5a9;">organont>elles. A decline in autophagy also plays an important role in aging and longevity. If the genes linked to autophagy are deleted in animals like the nematode C. elegans, a decrease in lifespan and early onset of aging can be observed.For his current research Robinson used the bacterium Salmonella typhimurium. With 13,823 reported cases

highly prevalent gene variants in minority populations cause kidney disease

IMAGE: Representative images of kidney tissue from APOL1-G1 and APOL1-G2 mice, showing severe scarring of the kidney filter.
view more Credit: Katalin Susztak, Perelman School of Medicine, University of PennsylvaniaPHILADELPHIA - African Americans have a heightened risk of developing chronic and end-stage kidney disease. This association has been attributed to two common genetic variants - named G1 and G2 -- in APOL1, a gene that codes for a human-specific protein. However, direct evidence showing that these variants definitively cause kidney disease was lacking because APOL1 is widely expressed in different cell types but the gene is present in only some primates and humans. The challenge has been to create an animal model to prove this. Now, a team led by researchers from the Perelman

abnormal development of the brain in an intractable disease, thanatophoric dyspl

[Background]Thanatophoric dysplasia (TD) is an intractable disease designated by Ministry of Welfare, Health and Labor (MWHL) of Japan, causing severe abnormalities of bones and the brain. The limb and rib bones are shorter than normal ones, and as regards the brain, abnormalities such as polymicrogyria*1 and periventricular nodular heterotopia (PNH)*2 are discerned. As a gene responsible for TD, fibroblast growth factor receptor 3 (FGFR3) has been reported. However, since it is a rare disease and since it is difficult to obtain brain samples from human patients, the pathophysiology of TD is largely unknown, and effective therapy has not been established.
Concerning the bone abnormalities in TD patients, a team of Kyoto University reported the research results using iPS cells (Nature 201

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