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 preliminary brca variations may work alongside comt variation to reduce breast cancer
preliminary: brca variations may work alongside comt variation to reduce breast

WASHINGTON (May 25, 2017) -- Research looking at genomic data from women with a genetic risk for breast cancer, who may never develop cancer, found their cancer-free state may be related to a second genetic variation. Researchers at the George Washington University (GW) found through looking at data of women with BRCA 1/2 genetic mutations, that some women also have the co-occurrence of a rare COMT genetic variant. The data set looked at women who volunteered for non-cancer related clinical trials, leading researchers to believe they have not developed cancer or have a family history of cancer."Not all mutation carriers develop the disease and the underlying reasons for this should be looked at, particularly with the large data sets now available to researchers," said Anelia Horvath, Ph.D.

brca testing on the rise for those without breast or ovarian cancers

GALVESTON, Texas - More women are requesting BRCA gene testing associated with certain types of cancer thanks to increased interest in the procedure. Traditionally women tested for mutations in the cancer-susceptibility genes BRCA1 and BRCA2 have been those diagnosed with early onset breast or ovarian cancer in order to guide treatment options.However, research suggests that the increase in women being tested may not necessarily mean better diagnosis of those at risk, according to a new study from researchers at The University of Texas Medical Branch at Galveston.Study findings published in the American Journal of Preventive Medicine found that during the past decade, the use of BRCA testing, a blood test that can identify harmful gene mutations has gradually shifted from primarily cancer

significant increase in number of women tested for brca gene, but many high-risk

Ann Arbor, MI, March 22, 2017 - Discovery of the BRCA genetic mutation in the mid-90s represented a breakthrough in breast and ovarian cancer prevention. About 5-10% of breast cancer cases and 10-18% of ovarian cancer cases can be attributed to two BRCA mutations. Testing for these genetic abnormalities has risen steadily over the past decade. Previously, mainly women with a history of cancer were referred for genetic testing, but as awareness has grown, more low-risk women are undergoing BRCA testing. A new study in the American Journal of Preventive Medicine found that the proportion of women without a history of cancer who underwent BRCA testing rose sharply from 24.3% in 2004 to 61.5% in 2014."It is estimated that 60%-80% of patients referred for genetic counseling and testing do not m

blood test offers improved breast cancer detection tool to reduce use of breast

NEW YORK, May 23, 2017 - A new study published in Clinical Breast Cancer demonstrates that Videssa® Breast, a multi-protein biomarker blood test to detect breast cancer, can help inform better decision-making after abnormal mammogram or other breast imaging results and potentially reduce use of biopsy by up to 67 percent. The study evaluated the performance of Videssa Breast among women under age 50.
With about 1.6 million breast biopsies performed each year,1 the implications of a blood test that can help clinicians confidently rule out breast cancer and avoid a potentially unnecessary biopsy are tremendous," said Judith K. Wolf, MD, Chief Medical Officer of Provista Diagnostics, Inc."We know imaging has limitations, especially among women under age 50 who, because of confounding factor

half a bottle of wine a week enough to put breast cancer survivors at risk

Drinking just one standard glass of wine a day may increase the risk of breast cancer returning for survivors of the common disease.New research from Cancer Council Victoria shows that the equivalent of 60 ml of wine a day, or approximately half a bottle a week, could be enough to increase the risk of breast cancer recurrence.
Breast cancer survivors have been warned about their wine intake.  Photo: ljubaphotoWith the overall five-year survival rate for breast cancer at 90 per cent, the research shows there's an important need to update the current public health advice on alcohol consumption to include those diagnosed with cancer.No more than two standard drinks per day for healthy men and women is recommended to reduce the risk of alcohol associated harms."These results show that as lit

new study: aggressive breast cancer grows faster in obese environment

It's not just what's inside breast cancer cells that matters. It's also the environment surrounding cancer cells that drives the disease, according to researchers at the University of North Carolina Lineberger Comprehensive Cancer Center.
In an abstract that will be presented April 3 at the American Association for Cancer Research Annual Meeting 2017, researchers will report their preliminary findings that cancer cells grew faster when they were transplanted into fatty, obese tissue. They believe the study can help explain the obesity cancer link, providing evidence that elements of the fatty tissue surrounding cancer cells may help the cancer to grow."We're interested in something called the 'microenvironment,' which is basically cells around the tumor and the chemicals those cells produ

soy food consumption linked to prolonged survival in some breast cancer patients

New research indicates that dietary soy products are safe and even beneficial for women diagnosed with breast cancer. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings may help resolve controversies over soy's potential link to breast cancer outcomes.Soy foods are considered among the healthiest for human consumption, but their estrogen-like properties have raised concerns of a potential increased risk of breast cancer. This is because in hormone receptor-positive cancer, the most common form of the disease, there are some concerns that high estrogen levels help cancer cells grow and spread, though this remains controversial."Isoflavones--the component of soy that has estrogen-like properties--have been shown to slow the growth of breast

the link between alcohol and breast cancer is stronger

The scientific link between alcohol and breast cancer is strong, but most of the research backing it has been done in white women, not diverse groups of women.Now, in a new analysis published in Cancer Epidemiology, Biomarkers & Prevention, scientists find the same risk among black women. They studied more than 22,000 women in the African-American Breast Cancer Epidemiology and Risk Consortium, in which the women answered questionnaires about their alcohol habits. Their answers were correlated with records of breast cancer diagnoses. Women who reported drinking more than seven drinks a week had a higher risk of breast cancer of nearly all types compared to women who drank less. Women who drank 14 or more alcohol beverages weekly had a 33% higher chance of developing breast cancer than wome

soy may help breast cancer patients to live longer

Maximilian Stock Ltd.—Getty ImagesThere is perhaps no more complicated and fraught connection between cancer and food than the one between breast cancer and soy.When studies first revealed that women in Asian countries who eat a significant amount of soy daily were less likely to die of breast cancer or experience recurrence than women who consumed less soy, many took it to mean that soy-based foods may have protective qualities. Other studies, meanwhile, found that soy may interfere with anti-cancer drugs, while others suggested that certain properties in soy mimic estrogen—which can fuel some breast cancers—and should therefore be avoided.There's been plenty of back and forth, but new research helps to clear up the confusion. In the latest study on the subject, researchers led by Dr. Fan

longmont's parascript partners with new zealand's volpara on early breast cancer

Longmont-based software company Parascript partnered with New Zealand tech firm Volpara to help advance technology for breast cancer detection.Volpara offers software to measure breast density, a difficult feature to detect with conventional mammography. Breast density has been shown in studies to be a predictor of breast cancer risk.Parascript has developed AccuDetect Computer-Aided Detection (CAD) that will work in tandem with Volpara's technology."This partnership with Volpara is a defining moment for us in early cancer detection for successfully fighting cancer," Gina Dailey, director of medical sales at Parascript, said in a statement. "VolparaDensity is a reliable volumetric breast density measurement tool that helps radiologists better consider who might benefit from additional scre

city of hope researchers discover how breast cancer spreads to the brain

DUARTE, Calif. -- Ninety percent of cancer deaths are from cancer spread. Breast cancer patients, for example, typically do not die because cancer returns in their breast, they die because it spreads to other parts of their body. The most dangerous of which is the brain. Approximately 40 percent of all women with HER2-positive breast cancer will develop brain metastases. Now City of Hope researchers have found how this happens. Breast cancer cells wrap themselves in reelin -- a protein typically found only in the brain -- that allows the cells to disguise themselves as "friend and not foe," avoiding a system in the brain designed to detect enemy cells. From these disguised cells, new deadly brain tumors form. "More women than ever are surviving breast cancer only to die from breast tumors

women at high risk for breast cancer more likely to get mri when informed direct

A study published in the journal Health Communications shows that women at high risk for breast cancer who received a letter informing them of their options for additional imaging with contrast-enhanced MRI of the breast (in addition to a letter sent to their primary care physician) were more likely to return to the center for additional screening with MRI. The letter, which is included in the published paper, may help breast imaging centers navigate the complex legal, ethical and institutional landscapes in a way that increases the likelihood that women will follow through with American Cancer Society breast cancer screening recommendations for adjunct breast screening in women at elevated risk. The project is a collaboration between Invision Sally Jobe Breast Centers, which contributed t

study confirms link between alcohol consumption, breast cancer risk in black wom

CHAPEL HILL - Alcohol consumption is known to be a risk factor for breast cancer based on studies predominately done in white women. Now a University of North Carolina Lineberger Comprehensive Cancer Center study has found the same risk exists for black women, an understudied group.Researchers found in the new study that black women who drank more than 14 alcoholic drinks per week had a significantly higher risk of invasive breast cancer than those who drank less. The findings, published in the journal Cancer, Epidemiology, Biomarkers & Prevention, confirmed the link between alcohol consumption and breast cancer risk, which has been seen in other studies drawn from majority white populations.And while some breast cancer risk factors - like age or genetics -- aren't easily modified, alcohol

just one alcoholic drink a day increases breast cancer risk, exercise lowers ris

WASHINGTON, DC -- Drinking just one glass of wine or other alcoholic drink a day increases breast cancer risk, finds a major new report by the American Institute for Cancer Research (AICR) and the World Cancer Research Fund (WCRF).The report also revealed, for the first time, that vigorous exercise such as running or fast bicycling decreases the risk of both pre- and post-menopausal breast cancers. Strong evidence confirmed an earlier finding that moderate exercise decreases the risk of post-menopausal breast cancer, the most common type of breast cancer."It can be confusing with single studies when the findings get swept back and forth," said Anne McTiernan, MD, PhD, a lead author of the report and cancer prevention expert at the Fred Hutchinson Cancer Research Center."With this comprehen

researchers identify nutrient metabolism that drives breast tumor metastasis

A multinational group of scientists, led by professor Sarah-Maria Fendt (VIB-KU Leuven), have discovered that breast cancer cells that have invaded other organs rely on a different nutrient metabolism to produce energy than normal cells and non-metastasizing cancer cells. To demonstrate their findings, the researchers used mouse models to show that inhibiting energy production from this nutrient metabolism reduces the occurrence of metastases by more than 60%. This discovery could result in new breast cancer therapies that prevent metastases by targeting this metabolic process. These groundbreaking insights are published in the leading scientific journal Nature Communications. Breast cancers that invade other organs almost always result in the patient's death. Even more, scientists have ye

fda clears 23andme to warn you about potential health risks

The conditions in question are Parkinson's disease, late-onset Alzheimer's, Celiac disease, Alpha-1 antitypsin deficiency, early-onset primary dystonia, factor XI deficiency, Gaucher disease type 1, G6PD, hereditary hemochromatosis and hereditary thrombophilia."This is an important moment for people who want to know their genetic health risks and be more proactive about their health," 23andMe CEO and co-founder Anne Wojcicki said in a statement. "The FDA has embraced innovation and has empowered individuals by authorizing direct access to this information. It is a significant step forward for 23andMe and for the adoption of personal genetics."What the clearance doesn't cover are using the tests as a diagnostic procedure for things like BRCA (gene mutations that can lead to breast and ovari

risks of getting breast implants, according to a surgeon

There are risks involved in every surgical procedure, but this is one you may not have expected: The FDA recently reported 359 cases and nine deaths from a rare cancer linked to breast implants.The cancer is anaplastic large cell lymphoma (ALCL), which impacts the cells around the implant. This non-Hodgkin’s lymphoma is not a form of breast cancer, but can rather be found in the skin or lymph nodes. "It has presented in women who had problems with the implant, like lumps or asymetry," says Dr. Clara Lee, a reconstructive surgeon at the Ohio State University Comprehensive Cancer Center.Women have breast implants for two reasons: augmentation or reconstruction after mastectomies. The cancer could develop in either situation, though the risk is low. ALCL is estimated to occur in 1 in 300,000

pink ribbon walk | riviera insider

On Sunday 12th March, the fifth annual Pink Ribbon Walk will take place in Monaco. Supporting breast cancer victims and raising awareness on the methods of early breast cancer detection are at the centre of the association’s work, and the walk will involve hundreds of women, men and children dressed in the signature pink t-shirts.“Pink Ribbon Monaco aims to raise awareness on methods of early breast cancer detection and prevention through various campaigns and events,” say organisers. “Pink Ribbon Monaco works closely with medical professionals to provide assistance and support when and where it is needed. With the backing and guidance of the Centre Hospitalier Princesse Grace, we will target the areas in need of assistance. Our breast cancer awareness campaigns aim to educate the general

different breast cancer treatment options vary widely in their cost-effectivenes

A new study published today in the Journal of the National Cancer Institute indicates that different therapies for early-stage breast cancer have very different relative values. Some therapies may have fewer complications and be much less expensive than others. Women may be making treatment decisions based on factors other than medical value.Recommended options for early breast cancer include lumpectomy plus whole breast irradiation therapy, lumpectomy plus brachytherapy, mastectomy alone, mastectomy plus reconstruction, and, in older women, lumpectomy alone. Researchers performed a comparative examination of each treatment's complications and cost to assess their relative values.Researchers identified 105,211 women with early breast cancer diagnosed between 2000 and 2011 and identified tr

stereotactic partial breast radiation lowers number of treatments to 5

IMAGE: Dr. Asal Rahimi (left) recommended a new stereotactic partial breast radiation treatment for Leslie LeBlanc. A new study showed that stereotactic partial breast radiation was as safe as traditional radiation...
view more Credit: UT Southwestern Medical CenterDALLAS - May 8, 2017 - UT Southwestern Medical Center researchers found in a recent phase one clinical trial that stereotactic partial breast radiation was as safe as traditional radiation but decreased treatment time from six weeks to just days.UT Southwestern's Harold C. Simmons Comprehensive Cancer Center is the only site in Texas and one of a few in the world to offer stereotactic partial breast radiation treatment to early-stage breast cancer patients."Standard breast cancer treatments are delivered daily to the entire br

vale vanessa sutton, wife, mother and another human face to the toll of breast c

"Hello, Mummy!"Four-year-old Stephanie Sutton innocently calls out to her mum as she gleefully throws a balloon towards the sky.
Mark Sutton and children Will 13, Samantha, 15, and Stephanie, 4, with balloons they held recently for an early birthday party for their wife and mother Vanessa Sutton who passed away on Saturday.
The sculpture was placed outside their Weetangera home by Vanessa's sister Megan Croker in her memory. Photo: Jamila ToderasHer mum, Vanessa, passed away at home in Weetangera last Saturday. Her funeral is on Friday. The balloons were left over from an early surprise birthday party the family held for Vanessa. She was supposed to turn 46 next week. Friends crowd-funded to pay for the funeral.Vanessa had been living with metastatic breast cancer for almost four years

higher odds of late breast cancer diagnosis in isolated white communities, resea

Living in a segregated white community has been associated with higher odds of being diagnosed with late-stage breast cancer, according to a recent study led by a researcher in the School of Public Health at Georgia State University.Although white women generally are at relatively low risk of such diagnoses nationwide, the study's findings "suggest there may be a widespread problem in highly isolated white communities, which are perhaps an understudied 'reverse disparity' bearing further thought and future investigation," the researchers said. The study's finding "is consistent with recent reports of a rise in U.S. mortality rate that is being driven by rapidly increasing white mortality," the researchers also noted.The study is published in the International Journal of Environmental Resea

mayo breast cancer study provides critical information on tumor sequencing and c

ROCHESTER, Minn. -- Tumor sequencing is increasingly used to select treatment for patients with cancer, but its role in women with newly diagnosed breast cancer is unknown. Mayo Clinic researchers reported today in the Journal of the National Cancer Institute the results of a prospective tumor sequencing study in women receiving chemotherapy prior to breast surgery. The goal was to determine whether tumor genomic alterations could differentiate patients with chemotherapy sensitive and chemotherapy resistant disease and to generate patient-derived xenografts (mouse avatars) to validate their findings."There is great interest to use tumor sequencing data to guide therapy," says Matthew Goetz, M.D., medical oncologist and co-chair of the Breast Cancer Genome-Guided Therapy (BEAUTY) study. "Ho

alcohol is associated with higher risk of breast cancer in african-american wome

Bottom Line: Alcohol consumption was associated with an increased risk of breast cancer in a large study of African-American women, indicating that they, like white women, may benefit from limiting alcohol.Journal in Which the Study was Published: Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.Author: Melissa A. Troester, PhD, a professor of epidemiology and director of the Center for Environmental Health and Susceptibility in the Gillings School of Global Public Health at the University of North Carolina.Background: Alcohol is an established risk factor for breast cancer; however, most studies have been conducted in predominantly white populations. The researchers wanted to discern whether alcohol raises risk for African-American wo

penn researchers use new imaging to show key enzyme in ovarian cancer

PHILADELPHIA - A new imaging test may provide the ability to identify ovarian cancer patients who are candidates for an emerging treatment that targets a key enzyme cancer cells need to survive. Currently, epithelial ovarian cancer patients with BRCA1 mutations are considered candidates for the treatment, but there is no method to measure the enzyme levels to help guide treatment choices. Researchers from the Perelman School of Medicine at the University of Pennsylvania used a new type of imaging to do just that in hopes of finding patients who may benefit from treatment to block the enzyme, including patients without the BRCA mutation. Researchers will present their findings at the upcoming 2017 American Association for Cancer Research Annual Meeting in Washington, D.C. (Abstract 3716).

perth doctor's new cancer centre dream

A Perth oncologist who has revolutionised breast cancer treatments globally has unveiled a plan to expand her research base into a one-stop world class cancer treatment centre.Since being founded by Arlene Chan in 2000, Australia's busiest breast cancer trials unit, Nedlands' Breast Cancer Research Centre WA, has run 84 trials. 
Professor Arlene Chan hopes to make huge changes to the way breast cancer is treated in WA.  Photo: SuppliedEleven of those trials have changed the way the disease is treated internationally, with two leading to 50 per cent survival rate increases.Professor Chan still sees patients, and recommends them to appropriate trials – meaning the not-for-profit lets thousands of Perth residents access next-generation treatment for free, years ahead of others.It has been h

olivia newton-john postpones tour following new breast cancer diagnosis

Australian singer and actress Olivia Newton-John has revealed she has again been diagnosed with breast cancer and will postpone a number of planned tour dates as she embarks on treatment.A statement posted to her official Facebook page said the star of Grease and Xanadu was reluctantly cancelling some upcoming performances in the US and Canada after receiving the diagnosis.
Olivia Newton-John, pictured in 2014, revealed her diagnosis on Facebook. Photo: Getty"The back pain that initially caused her to postpone the first half of her concert tour, has turned out to be breast cancer that has metastasised to the sacrum," the post stated.The statement said the singer, who was first diagnosed with breast cancer in 1992, would undergo treatment that included photon radiation therapy, as well as

exposure to bpa substitute, bps, multiplies breast cancer cells

ORLANDO -- Bisphenol S (BPS), a substitute for the chemical bisphenol A (BPA) in the plastic industry, shows the potential for increasing the aggressiveness of breast cancer through its behavior as an endocrine-disrupting chemical, a new study finds. The results, which tested BPS in human breast cancer cells, will be presented Saturday at ENDO 2017, the Endocrine Society's 99th annual meeting in Orlando, Fla.BPS is found in polycarbonate hard plastics, currency bills and thermal paper receipts as well as many products touted to be free of BPA, a known endocrine-disrupting chemical suspected of having multiple possible health risks. "Despite hopes for a safer alternative to BPA, studies have shown BPS to exhibit similar estrogen-mimicking behavior to BPA," said the study's principal investi

study estimates number of us women living with metastatic breast cancer

A new study shows that the number of women in the United States living with distant metastatic breast cancer (MBC), the most severe form of the disease, is growing. This is likely due to the aging of the U.S. population and improvements in treatment. Researchers came to this finding by estimating the number of U.S. women living with MBC, or breast cancer that has spread to distant sites in the body, including women who were initially diagnosed with metastatic disease, and those who developed MBC after an initial diagnosis at an earlier stage.The researchers also found that median and five-year relative survival for women initially diagnosed with MBC is improving, especially among younger women. The study was led by Angela Mariotto, Ph.D., chief of the Data Analytics Branch of the Division

newly discovered vulnerability in an aggressive breast cancer provides therapeut

Triple-negative breast cancer quickly becomes resistant to current therapies, leaving patients no therapeutic options.
BIDMC researchers discovered that TNBC cells increase production of pyrimidine nucleotides in response to traditional chemotherapy.
Discovery represents a vulnerability that can be exploited by blocking pyrimidine using an existing inhibitor in combination with chemotherapy. BOSTON - Physicians currently have no targeted treatment options available for women diagnosed with an aggressive form of breast cancer known as triple-negative breast cancer (TNBC), leaving standard-of-care chemotherapies as a first line of defense against the disease. However, most women with TNBC do not respond to these broadly-targeted chemotherapies, and those who do often develop resistance to

genetic association with aggressive prostate cancer discovered

IMAGE: Dr. Alexandre Zlotta led the study identifying a genetic association with aggressive prostate cancer.
view more Credit: Courtesy of Mount Sinai Hospital, Toronto, CanadaMarch 16, 2017 (Toronto) - An international study published in the Journal of the National Cancer Institute has identified a genetic connection to the aggressive form of prostate cancer. The study showed a threefold increase in the risk of aggressive prostate cancer for men with the genetic mutation. The frequency of the gene variants varied from 6 to 14% of the population of men with prostate cancer.Much like the association between BRCA gene mutation and the risk for breast cancer in women changed the approach to treatment/ prevention, the identification of the Kallikrein 6 gene region may change the course of pr

different databases, differing statistics on racial disparities in immediate bre

March 30, 2017 - Three major national databases include varying estimates of racial gaps in the use of immediate breast reconstruction (IBR) after mastectomy for breast cancer, reports a study in the March issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). All three databases report continued increases in the number of women benefiting from immediate breast reconstruction -- but with varying disparities among racial/ethnic minority patients. "Since these large databases play an important role in making healthcare policy, it's important to appreciate the significant differences in racial and socioeconomic disparities in IBR," comments ASPS Member Surgeon Samuel J. Lin, MD, MBA, of Harvard Medical School.Variation in

can latina breast cancer patients and their doctors bridge the cultural divide?

IMAGE: This is Steven J. Katz, M.D., M.P.H.
view more Credit: Michigan MedicineANN ARBOR, Michigan - The largest study to date of how Latina breast cancer patients evaluate treatment options highlights the need to counteract language barriers, information overload and a tendency to defer to rather than partner with doctors.
The new research from the University of Michigan appears in the journal Cancer. It builds upon previous Michigan Medicine studies of doctor-patient communication and decision making in breast cancer. About the studyMore than 5,000 newly diagnosed women with breast cancer from Los Angeles County and the state of Georgia were surveyed. In designing the study, nearly 100 survey tools were reviewed and considered to ensure that data collection accurately reflected the ex

report: younger women battling breast cancer face more aggressive diagnoses

RESEARCH TRIANGLE PARK, NC-- As the nation struggles with soaring health care costs, a new report by RTI International shows that younger women diagnosed with breast cancer face a significant treatment burden.The report, published in Breast Cancer Research and Treatment, estimates the cost of breast cancer among women 45 years and younger. "Younger women diagnosed with breast cancer often face more aggressive treatment, and are therefore more vulnerable to financial hardships," said Benjamin T. Allaire, report author and research economist at RTI. "This hardship leads some to forgo or delay necessary treatments, which may lead to immediate or future complications."Analyzing data from the North Carolina Central Cancer Registry, report authors found that with private health insurance younger

cutting down on cancer surgeries

IMAGE: Terence T. W. Wong, first author of the May 17 Science Advances paper, adjusts a photoacoustic microscope at the Caltech Optical Imaging Laboratory.
view more Credit: CaltechEngineers at the Optical Imaging Laboratory led by Caltech's Lihong Wang have developed an imaging technology that could help surgeons removing breast cancer lumps confirm that they have cut out the entire tumor--reducing the need for additional surgeries. About 300,000 new cases of invasive breast cancer are discovered annually. Of these, 60 to 75 percent of patients underwent breast-conserving surgery.Breast-conserving surgeries, or lumpectomies, attempt to remove the entire tumor while retaining as much of the undamaged breast tissue as possible. (In contrast, a mastectomy removes the entire breast.) The ex

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