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 transcription factor
plant cells survive but stop dividing upon dna damage

IMAGE: Green spots indicate a transcription factor that accumulates and inhibits cell division upon DNA damage. Researchers found an indispensable role of the transcription factor in arresting plant growth under stressful...
view more Credit: Masaaki Umeda(Nara, Japan) The cell cycle is the system through which a cell grows and divides. It is also how a cell passes its DNA to its progeny and is why the cell cycle ceases if the DNA is damaged, as otherwise it risks passing this damage to daughter cells. Scientists at the Nara Institute of Science and Technology (NAIST) have reported a new molecular mechanism that explains how this cessation occurs. The study, which can be read in Nature Communications, shows the transcription factor family MYB3R prevents progression to the division stage

visualization of transcription initiation at single-molecule resolution

A novel approach developed at the Friedrich Miescher Institute for Biomedical Research (FMI) has allowed scientists in Dirk Schübeler's group to dissect and quantify the individual steps of transcription initiation. Unexpectedly, they observed that RNA polymerases frequently dissociate from the DNA template, rather than pause, before transcription continues. They thus gained new mechanistic insights into gene regulation.

transcription factor expression tied to medial amygdala neuronal id, sex-specifi

IMAGE: This is Joshua G. Corbin, Ph.D., principal investigator in the Center for Neuroscience Research at Children's National Health System.
view more Credit: Children's National Health SystemWASHINGTON - Neurons derived from two different types of precursor cells that later develop into neurons in the medial amygdala - one of the interconnected structures in the brain involved in emotion, motivation and memory - help to program innate reproductive and aggressive behaviors into the brain, research led by Children's National Health System indicates.The finding, published April 7, 2017 in the journal eLife, helps to explain how events that occur when the fetal brain is developing may program instinctual behaviors relied on by creatures big and small, such as avoiding predators, mating and

crystal structure reveals new details of nonstandard rna transcription

IMAGE: Schematic of alternative pathways for transcription elongation complex formation. During canonical transcription (left) the growing strand of RNA extends toward the RNA exit channel of RNA polymerase. New, high-resolution crystal...
view more Credit: Murakami laboratory, Penn State UniversityOut through the window: Crystal structure reveals details of nonstandard RNA transcriptionUniversity Park, PA -- High-resolution crystal structure reveals a new pathway for RNA during a nontraditional form of transcription -- the process by which RNA is produced from a DNA template. Caught during the act of reiterative transcription, a form of transcription in which a single base of DNA (represented by the letters A, T, C, and G) codes for several corresponding bases in the RNA (one G in DNA l

excess transcription factor heat shock factor 1 can delay embryonic neural migra

IMAGE: Kazue Hashimoto-Torii, Ph.D., principal investigator in the Center for Neuroscience Research at Children's National Health System and senior author of the paper published May 2 in Nature Communications, and her...
view more Credit: Children's National Health SystemWASHINGTON - Transcription factor Heat Shock Factor 1 (Hsf1), which the developing brain releases to shield the vital organ from the ravages of environmental stress, actually can contribute to impairing the embryonic brain when too much Hsf1 is produced, research led by Children's National Health System scientists indicates. While the finding was made in a preclinical model, it raises questions about neural risks for human infants if their mothers drink alcohol in the first or second trimester of pregnancy.When fetuses a

rattling dna hustles transcribers to targets

Imagine if a dense thicket didn't obstruct your path but instead picked you up and shuttled you through the forest. That's what tightly packed DNA might be doing with important life molecules to get them where they're needed on time.New simulations of DNA as a transport conduit could shatter the way scientists have thought about how large molecules called transcription factors diffuse on their way to carry out genetic missions, according to a study by researchers at the Georgia Institute of Technology. The simulations add important brush strokes to our picture of elusive inner mechanics of cells.The simulations strongly support the hypothesis that, in a live cell, DNA is in constant motion, making it the dominant mover of transcription factors, to their target sites on DNA. There, the fact

rattling dna hustles transcribers to targets

Naturally occurring DNA is in constant motion, researchers hypothesize, and transports large transcription factors (depicted in green) through its tangles until they reach sites where they bind and carry out their activity. Here a still image from a very large, unique simulation. Credit: Georgia Tech / Edmond Chow / Jeff SkolnickImagine if a dense thicket didn't obstruct your path but instead picked you up and shuttled you through the forest. That's what tightly packed DNA might be doing with important life molecules to get them where they're needed on time.
New simulations of DNA as a transport conduit could shatter the way scientists have thought about how large molecules called transcription factors diffuse on their way to carry out genetic missions, according to a study by researcher

preeclampsia triggered by an overdose of gene activity

Preeclampsia is the most dangerous form of hypertension during a pregnancy and can be fatal for both mother and child. Though it is known to originate in the placenta, the root causes remain largely a mystery. An international research team led by the Max Delbrück Center for Molecular Medicine (MDC) has recently published new findings in the scientific journal Circulation, which reveal that preeclampsia is not in fact a single disease caused solely by genetic factors. Their tests on placenta samples have shown that epigenetically regulated genes play an important role. The Berlin research team also developed an in vitro model of the disorder which demonstrates the dysregulation of an important transcription factor.The research team compared placental tissue samples and the genetic makeup o

unexpected regulation of transcription factors critical to development

A team of developmental biologists at the University of Massachusetts Amherst led by Dominique Alfandari, with others at MIT, report in a new paper that they have for the first time described how two transcription factors that are "absolutely essential for human development" are regulated by a cell surface metalloprotease known as ADAM13. The discovery adds to knowledge of how cells migrate in vertebrate embryos, how stem cells differentiate and how cancer cells metastasize.

study finds n-alpha-acetyltransferase d (natd) promotes lung cancer progression

Researchers at Nanjing University and their collaborators have found that NatD, which mediates N-alpha-terminal acetylation (Nt-acetylation) of histone H4, promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate the transcription factor Slug, a key regulator of the epithelial-to-mesenchymal transition (EMT). Their study results are published in the 13th October, 2017 issue of the journal Nature Communications (DOI:10.1038/s41467-017-00988-5).
This novel finding indicates that NatD is a crucial epigenetic modulator of cell invasion during lung cancer progression, implying a new therapeutic target for cancer treatment.
"These studies have demonstrated that NatD promotes the migratory and invasive capabilities of lung cancer cells both in vitro and in v

a protein that extends life of yeast cells

IMAGE: This is baker's yeast Saccharomyces cerevisiae.
view more Credit: (Image: University of Basel/SNI/Nano Imaging Lab)To understand and control aging is the aspiration of many scientists. Researchers at the Biozentrum of the University of Basel have now discovered that the protein Gcn4 decreases protein synthesis and extends the life of yeast cells. Understanding how individual genes affect lifespan opens new ways to control the aging process and the occurrence of aging-related diseases. The results of this study have recently been published in Nature Communications.For about one hundred years it has been known that nutrient restriction and moderate stress can significantly prolong life. The researchers led by Prof. Mihaela Zavolan and Prof. Anne Spang, both at the Biozentrum of the

ai takes the headaches out of transcribing voice recordings

Ask many interviewers about their least favorite part of the job and they'll almost always point to transcription. It can take hours to turn even a short chat into text, which is a serious pain for everyone from reporters to police interrogators. China tech giant Baidu may have a smarter approach: artificial intelligence. It just released a beta for SwiftScribe, a transcription app that uses a neural network to make sense of speech. The software not only promises relatively accurate speech-to-text processing thanks to training on "thousands of hours" of recordings, but learns from edits. It should account more for how people actually speak, saving you from making a load of edits.

researchers show how a cancer gene protects genome organization

CHAPEL HILL, NC - UNC School of Medicine researchers have cracked a long-standing mystery about an important enzyme found in virtually all organisms other than bacteria. The basic science finding may have implications for understanding cancer development and how to halt it.Researchers have known that the enzyme Set2 is important for transcribing genes - the process of making strands of RNA from the DNA. Transcription is critical for making proteins and other functional molecules. But Set2's precise role in transcription hasn't been clear. Now, UNC scientists discovered that the enzyme is particularly important for keeping transcription working properly when cells are under stress. Without Set2, cells that become stressed through the lack of nutrients begin mis-transcribing genes in a way t

anti-malaria drugs: potential new target identified

A newly described protein could be an effective target for combatting drug-resistant malaria parasites. The protein, the transcription factor PfAP2-I, regulates a number of genes involved with the parasite's invasion of red blood cells, a critical part of the parasite's complex life cycle that could be targeted by new antimalarial drugs. A paper describing the protein PfAP2-I and its role in the invasion process appears June 14, 2017 in the journal Cell Host & Microbe.

accessing dna in the cell's powerhouse to treat disease

A schematic illustration of a mitochondria-specific DNA-based synthetic ligand, called MITO-PIPs that selectively read a target DNA sequence and alter gene transcription. Credit: Kyoto University iCeMSFor the first time, a synthetic compound has been made that can bind to DNA in the cells' energy powerhouses, suppressing a gene associated with nerve and muscle disease.

Pyrrole-imidazole polyamides (PIPs) are compounds that can read specific DNA sequences inside living cells and silence disease-causing genes. They prevent proteins, called transcription factors, from binding to specific parts of the DNA strand, thus suppressing the transcription of DNA into RNA.Most DNA is found in the nucleus. But mitochondria, the cell's powerhouses, also host a small amount of DNA. PIPs are capable o

accessing dna in the cell's powerhouse to treat disease

IMAGE: This is a schematic illustration of a mitochondria-specific DNA-based synthetic ligand, called MITO-PIPs that selectively read a target DNA sequence and alter gene transcription.
view more Credit: Kyoto University iCeMSFor the first time, a synthetic compound has been made that can bind to DNA in the cells' energy powerhouses, suppressing a gene associated with nerve and muscle disease.Pyrrole-imidazole polyamides (PIPs) are compounds that can read specific DNA sequences inside living cells and silence disease-causing genes. They prevent proteins, called transcription factors, from binding to specific parts of the DNA strand, thus suppressing the transcription of DNA into RNA. Most DNA is found in the nucleus. But mitochondria, the cell's powerhouses, also host a small amount of D

how to enable 2-factor authentication on iphone and ipad

How do you set up Apple's two-factor authentication and how do you get verification codes? Here's what you need to know!Updated April 2017: As part of iOS 10.3, Set Up Assistant, the wizard that walks you through signing in on a new or newly updated iPhone or iPad, will now prompt you to enable 2-factor authentication if you haven't already. Do it.Apple originally implemented two-step verification but now two-factor authentication (2FA) is where it's at. The terms are contentious in the security community — some don't consider an out-of-band token to be sufficient as a second factor — but the bottom line is this: If you want something more than just your password to protect your Apple ID, which is used for iCloud, iTunes, and App Store, then you want 2-factor turned on.That way, if you use

transcription ensemble | athens | may 10 | what’s on

MONDAY MAY 8, 2017
WHAT’S ON | Greek EditionClassifiedsSubscriptionsFAVORITESNo favoritesTwitterFacebookTermWHAT'S ON
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Transcription Ensemble | Athens | May 10TAGS:MusicThe Transcription Ensemble – comprising Yiorgos Kandylidis on violin, cellist Christos Grimpas and Nikos Zafranas on piano – will perform works by Alexander Scriabin, Arthur Lourie, Paul Juon, Sergey Prokofiev and Dmitry Shostakovich inspired by photographs of Russian avant-garde art from the Costakis Collection that will be shown during the concert. The show starts at 8.30 p.m. and tickets cost 10 or 15 euros.
Athens Concert Hall, 1 Kokkali & Vassilissis Sofias,
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apple prompting ios 10.3 users to enable two-factor authentication w/ push notif

Apple has started prompting iOS 10.3 beta users to enable two-factor authentication with a new push notification. The prompt has only started appearing over the last 24 hours or so and seems to have hit most users in the middle of the night last night.If you swipe on the notification, you’re taken to a screen in the Settings app that explains what two-factor authentication is and how to enable it for maximum security. Additionally, there’s an option to learn more which brings up a longer explanation of the processor.Furthermore, if you open the Settings app and you don’t have two-factor authentication turned on, you’ll see a new warning at the top asking you to do so, even if you ignored this notification.Here’s what Apple says regarding two-factor in the Settings app:Two-factor authentica

sulforaphane, a phytochemical in broccoli sprouts, ameliorates obesity

IMAGE: The two functions of sulforaphane uncovered by the current study are; 1) ameliorating obesity by adipose tissue browning to augment energy consumption and 2) improving 'high-fat' gut bacterial flora and...
view more Credit: Kanazawa University[Background]Sulforaphane*1, a phytochemical contained in broccoli sprouts at relatively high concentrations, has been known to exert effects of cancer prevention by activating a transcription factor, Nrf2 (nuclear factor (erythroid-derived 2)-like 2), which regulates the balance of oxidation - reduction in the cell, and by enhancing anti-oxidation ability of the body and detoxication of chemical compounds taken into the body. On the other hand, when the balance of oxidation - reduction is deteriorated due to hyper nutrition and obesity, it ha

using networks to understand tissue-specific gene regulation

Researchers at Brigham and Women's Hospital have discerned that different tissue functions arise from a core biological machinery that is largely shared across tissues, rather than from their own individual regulators. In a paper published in Cell Reports, Kimberly Glass, PhD, of the Channing Division of Network Medicine, and her team explain how they have used PANDA (Passing Attributes between Networks for Data Assimilation) to create network models of the interactions between transcription factors and genes, finding that the presence of different tissue functions is the result of subtle, tissue-specific shifts in a regulatory network. For each of these tissue-specific functions, the network has the same core components, but they're combined in different ways with added genetic and enviro

using networks to understand tissue-specific gene regulation

Researchers at Brigham and Women's Hospital have discerned that different tissue functions arise from a core biological machinery that is largely shared across tissues, rather than from their own individual regulators. In a paper published in Cell Reports, Kimberly Glass, PhD, of the Channing Division of Network Medicine, and her team explain how they have used PANDA (Passing Attributes between Networks for Data Assimilation) to create network models of the interactions between transcription factors and genes, finding that the presence of different tissue functions is the result of subtle, tissue-specific shifts in a regulatory network. For each of these tissue-specific functions, the network has the same core components, but they're combined in different ways with added genetic and enviro

two-factor authentication comes to instagram

How do I set up and use Instagram's new two-factor authentication feature?Two-factor authentication is now available to everyone. This tool adds an extra layer of security to your Instagram account by requiring a code every time you log in. Tap the gear icon on your profile and choose Two-Factor Authentication to turn it on. (Instagram Blog)Last year, Instagram promised users that they would work on creating an abuse-free safe place for everyone while simultaneously building tools to "safeguard self-expression".On top of introducing new screens that will appear over "sensitive photos" – AKA photos that someone has reported that the review team agrees are slightly scandalous but not worthy of deleting – two-factor authentication has officially hit the 'Gram.Or, it will in the next couple of

mtv renews fear factor for second season

There's about to be some new ludicrous (see what we did there?) Fear Factor challenges: The series is returning for Season 2!MTV announced today (in advance of tonight's season finale) that the reinvented Ludacris-hosted program will return with 20 new episodes in 2018. More creepy critters and scary stunts are on the way (and shrieking, plenty of that too).“I’m looking forward to season two of Fear Factor and it being more ludicrous than the 1st season,” Ludacris said in a statement. “Pun intended.” What was your favorite Fear Factor Season 1 moment? Sound off in the comments and check out a sneak peek below from tonight's finale below (and be sure to watch at 10/9c).

two-factor authentication: everything you need to know!

Hackers are too good, and security systems flawed. Longer complicated passwords created by generators like Safari's iCloud Keychain or third party apps like LastPass or 1Password can help, but the best way to lock down your accounts is to add extra security options for two-step or two-factor (2FA) authentication. Here's how to go about it.What is two-factor authentication?Two-factor authentication is the most prevalent way to secure your accounts: It asks you to authenticate that you are who you say you are by supplying not only your password, but a unique code supplied from your phone or an external app. It ensures that those accessing your accounts have access to your physical devices as well as your virtual passwords, and makes a simple password crack or social engineering hack a lot mo

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